Crest is a brand of toothpaste made by Procter & Gamble in Germany and in the United States of America and sold worldwide. In many countries in Europe, such as Germany, Bulgaria, Serbia, Ukraine, Russia, Poland, Hungary and Romania, it is sold as Blend-A-Med, the name of an established Germantoothpaste acquired by P&G in 1987 (formerly Blendax GmbH, located in Mainz, Germany).
While toothpastes containing a fluoride as the active ingredient had already a long history. Crest was first introduced in the United States in 1955. At first it used stannous fluoride, marketed as “Fluoristan” (this was also the original brand name it was sold under—it was later changed from “Fluoristan” to “Crestwith Fluoristan”). The composition of the toothpaste had been developed by Drs. Muhler, Harry Day, and William H. Nebergall at Indiana University, and was patented by Nebergall.
Info gleaned from Wikipedia